cpstunnaz
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Post at 21-7-2010 08:35  Profile P.M. 
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New Gel Cuts HIV Transmission in Half

(CNN) -- A new topical gel has shown promise in helping to protect women from HIV infection, according to a study being presented at the International AIDS Conference in Vienna, Austria.

The gel contains the antiretroviral drug tenofovir, which keeps the virus from multiplying.

An effective vaginal microbicide such as this could be a major new tool in the HIV toolbox.

"Women represent the majority of new HIV infections globally, and urgently need methods they can control to protect themselves from infection," said Dr. Kevin Fenton, director of the National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, part of the Centers for Disease Control.

The two-and-a-half-year-old CAPRISA trial followed nearly 900 HIV-negative, sexually active South African women between ages 18 and 40 to determine how safe and effective tenofovir gel was in preventing HIV infection.

Researchers found the gel overall reduced infection by 50 percent after a year and 39 percent after 30 months. In women who used the drug consistently infection was reduced 54 percent. The gel was used up to 12 hours before and within 12 hours of sexual intercourse. The study found the gel also reduced the risk of genital herpes by 51 percent.

This is the first completed study on an antiretroviral microbicide. In the double-blind, randomized control trial, half the women got tenofovir gel and half got a placebo. Information from this trial could help researchers develop more antiretroviral-based microbicide drugs in the future.

Antiretrovirals can prevent retroviruses like HIV from reproducing and damaging the immune system.

A separate study presented at the conference found that a microbicide that is 40 to 50 percent effective could prevent nearly 300,000 to 600,000 new infections in a 10-year period.

Tenofovir is marketed by Gilead Sciences under the trade name Viread. It belongs to a class of drugs called reverse transcriptase inhibitors. They don't kill the virus but they slow down its growth, which ultimately slows the progression of the disease.

The therapy is not yet ready for widespread use, but the finding is a giant step forward in the use of microbicides, said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

"The results of the CAPRISA study are important and of considerable significance for the field of microbicides," Fauci said. "This is the first study that has shown a clear-cut positive effect of a microbicide on blocking acquisition of HIV infection.

"It is noteworthy that this is the first completed study that utilized a specific antiretroviral drug in the formulation. The important goal for the immediate future is to improve upon these results, however it is clear that this is a conceptual advance."

The Centers for Disease Control and Prevention called the results an exciting step forward.

"While these findings may need to be confirmed by other research to meet requirements for licensure by FDA and other regulatory bodies throughout the world, they suggest that we could soon have a new method to help reduce the heavy toll of HIV among women around the world," said the CDC's Fenton.

"It is also very encouraging that the study found that the microbicide significantly reduced the risk of genital herpes (HSV-2), which is common in developing countries and in the United States, and facilitates HIV transmission."

In another trial called PrEP -- pre-exposure prophylaxis -- the CDC is also studying whether antiretroviral pills are safe and effective in preventing HIV infection. That study is looking at several at-risk populations including gay men, IV-drug users and heterosexuals. Those results are expected sometime next year.


http://www.cnn.com/2010/HEALTH/0 ... otection/index.html
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easygoing78
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Post at 21-7-2010 09:12  Profile P.M. 
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girls only? not fair at alll
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Fifa
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Post at 21-7-2010 10:35  Profile P.M. 
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Wow! There has been so many minuscule findings towards H.I.V elimination that I always wander how much more research is really missing from the whole puzzle - certainly quite a lot as even this gell is not ready to be commercialized for widespread use.
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xiaodidi
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Post at 21-7-2010 10:39  Profile P.M. 
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flinger
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Post at 21-7-2010 11:24  Profile P.M. 
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Umm 50% better still leaves a lot to be desired, I'm still thinking I'd rather play it safe
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TonyToro
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Post at 21-7-2010 21:13  Profile P.M. 
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QUOTE:
Originally posted by cpstunnaz at 21-7-2010 08:35
(CNN) -- A new topical gel has shown promise in helping to protect women from HIV infection, according to a study being presented at the International AIDS Conference in Vienna, Austria.

The gel con ...

good info. they can put a man on the moon for crying out loud so why now??? imagine if STD's could be completely eradicated! What a joyful world we'd live in! BBFS for all!
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gangster
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Post at 21-7-2010 23:06  Profile P.M. 
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Reply #6 TonyToro's post

Yeah, seriously, who the hell came up with STDs in the first place? Absolute ridiculous tragedy of mankind.
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princeandnpg (Funk Junky)
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Post at 22-7-2010 04:16  Profile P.M. 
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I'm always in two minds about things like this gel.

They say that it's designed so that girls in Africa whose bfs and husbands refuse to wear condoms can still have some level of protection against HIV.

Am I the only one who thinks that we should all move en-masse to a world where women aren't forced to have unsafe sex against their wills?

The worrying thing is that the guys might now start saying that they don't need to wear a condom because of this gel that reduces the risk.

I'm all for medical advances, but the vast majority of STDs that us punters are so afraid of would be eradicated in a generation if people would just suit up all the time.  Isn't it worth it, so that our children can get regular lays in an STD-free world?
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asianaddict69
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Post at 22-7-2010 05:09  Profile P.M. 
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50% is still a big risk, just put a jacket on.
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rockypop
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Post at 22-7-2010 08:02  Profile P.M. 
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i don't know if this helps anything, but being one step to elimination is better than nothing i guess.

who wants to get HIV in the first place. they should offer more free condoms to help the cause.
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Fifa
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Post at 22-7-2010 08:50  Profile P.M. 
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Reply #7 gangster's post

The chimpanzee. Nobody can verify this theory (just as the Big Bang theory) but it is believed that eating meat of an infected chimpanzee deformed the virus to spread into humans via body fluid transmission.

Sometimes I think that instead of spending all this money into research, why not spend all the money to just located the currently infected and leave them all in a controlled but not so unethical environment so as to contorl their sexual partners and sex practices until they die. This will permanently solve the problem. Heck, such a campaign would probably save further money for donation to the poor kids in africa.

Recent Ratings
sirtiger   23-7-2010 02:50  Acceptance  -6   holy batman theories!!!
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alfredku
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Post at 22-7-2010 14:06  Profile P.M. 
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I think this is only a partial solution in HIV protection and precaution.
Hopefully, further research would increase the success rate.
At the mean time, wearing condom is still the first choice.
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princeandnpg (Funk Junky)
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Post at 23-7-2010 02:43  Profile P.M. 
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Reply #11 Fifa's post

Can we quarantine people who make stupid comments too in order to rid the world of stupidity?  

You don't need to quarantine the people, Fifa, just quarantine their bodily fluids with a bit of latex.
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wgok
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Post at 15-8-2010 07:23  Profile P.M. 
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don't trust these early results. even 50% cut in transmission is 50% to small.
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sron63
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Post at 15-8-2010 10:08  Profile P.M. 
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Reply #11 Fifa's post

Remember, even if you keep all infected person and well controlled...
New virus will keep coming to visit this world.

And, we can't actually do this well for isolation. We got billions of people in this world.
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jlee811
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Post at 15-8-2010 12:18  Profile P.M. 
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50% sounds like a good start, hopefully they make big strides with this in the next few years. It would certainly be a big weight off our shoulders, for sure...
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