I once had it in Thailand after an overnight punt, girl woke up in the morning and ran to the bathroom. I was shocked to then notice a trail of blood on the plush (5-star) hotel carpet all the way from the bedroom to the bathroom.
Girl was very embarrassed/ apologetic, but it was difficult trying to explain to the hotel cleaner that I'd had a 'nosebleed' and they would probably need to hire a professional cleaner.
Thankfully they didn't charge me for the cost!